Pueblo, Colorado is a city located in the southern part of the state, about 100 miles south of Denver. It is the county seat of Pueblo County and is the home of Colorado State University-Pueblo. The city has a population of around 110,000 people, making it the state's fourth-largest city. In the southeastern part of Colorado, in the Arkansas River Valley. It is situated about midway between the cities of Denver and Santa Fe, New Mexico. Pueblo is often referred to as the "Ste